copy number Search Results


copy number variation tars mm00438890 cn  (Thermo Fisher)
94
Thermo Fisher copy number variation tars mm00438890 cn
Copy Number Variation Tars Mm00438890 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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copy number variation cenpf hs03027722 cn  (Thermo Fisher)
85
Thermo Fisher copy number variation cenpf hs03027722 cn
Copy Number Variation Cenpf Hs03027722 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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copy number variation atg7 hs06623870 cn  (Thermo Fisher)
94
Thermo Fisher copy number variation atg7 hs06623870 cn
Copy Number Variation Atg7 Hs06623870 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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copy number variation sts hs00091141 cn  (Thermo Fisher)
85
Thermo Fisher copy number variation sts hs00091141 cn
Assessment of the cell line identity and the genomic integrity of the six MSA patient-derived iPSCs. (A) Short tandem repeat profiling provided the number of repeating units of 16 polymorphic microsatellite loci, to compare the donor fibroblast cells (reference) and the generated iPSCs and verify their origin. (B) G-banding revealed that the six iPSC lines showed a normal diploid karyotype (n = 46) and matched the sex of the donor patient. (C) Digital PCR allowed us to screen whether specific genomic regions accumulated duplications that may give a strong selective survival or growth advantage to iPSCs. Example of the scatter digital PCR plots displaying simultaneously (1) FAM signals, shown in purple and green to detect the target gene ( ID1 , NCAPD2 , PITX1 , RPS6KB1 , SOAT1 , or <t>STS</t> ), which are located in the 6 most recurrent abnormal regions; and (2) VIM signals, shown in orange and green to detect the reference gene, RPP30 . The ratio between the number of copies of the target gene and of the reference gene was used to determine the normal 2-copy number or copy number variations. The plots were obtained through QuantStudio 3D Digital PCR system. In all cases, we obtained 2-copy number (D) Quantitative Real Time RT-PCR was used for confirming the absence of the Sendai virus in the iPSC lines after 8 passages, through four primer sets (SeV, KOS, Klf4 and c-Myc). Box and Whisker plots depict in log10 scale the gene expression relative to GAPDH gene and normalized to the 7 days post-transduction fibroblasts, calculated by the 2(-ΔΔC(T)) method. In all iPSC clones, the expression levels of the SeV RNA were very low, reaching the limit of detection. Data are shown as the mean ± s.d. n = 3.
Copy Number Variation Sts Hs00091141 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 85 stars, based on 1 article reviews
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copy number variation alg1 mm00441726 cn  (Thermo Fisher)
90
Thermo Fisher copy number variation alg1 mm00441726 cn
Assessment of the cell line identity and the genomic integrity of the six MSA patient-derived iPSCs. (A) Short tandem repeat profiling provided the number of repeating units of 16 polymorphic microsatellite loci, to compare the donor fibroblast cells (reference) and the generated iPSCs and verify their origin. (B) G-banding revealed that the six iPSC lines showed a normal diploid karyotype (n = 46) and matched the sex of the donor patient. (C) Digital PCR allowed us to screen whether specific genomic regions accumulated duplications that may give a strong selective survival or growth advantage to iPSCs. Example of the scatter digital PCR plots displaying simultaneously (1) FAM signals, shown in purple and green to detect the target gene ( ID1 , NCAPD2 , PITX1 , RPS6KB1 , SOAT1 , or <t>STS</t> ), which are located in the 6 most recurrent abnormal regions; and (2) VIM signals, shown in orange and green to detect the reference gene, RPP30 . The ratio between the number of copies of the target gene and of the reference gene was used to determine the normal 2-copy number or copy number variations. The plots were obtained through QuantStudio 3D Digital PCR system. In all cases, we obtained 2-copy number (D) Quantitative Real Time RT-PCR was used for confirming the absence of the Sendai virus in the iPSC lines after 8 passages, through four primer sets (SeV, KOS, Klf4 and c-Myc). Box and Whisker plots depict in log10 scale the gene expression relative to GAPDH gene and normalized to the 7 days post-transduction fibroblasts, calculated by the 2(-ΔΔC(T)) method. In all iPSC clones, the expression levels of the SeV RNA were very low, reaching the limit of detection. Data are shown as the mean ± s.d. n = 3.
Copy Number Variation Alg1 Mm00441726 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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copy number variation vps13b mm00446968 cn  (Thermo Fisher)
92
Thermo Fisher copy number variation vps13b mm00446968 cn
Assessment of the cell line identity and the genomic integrity of the six MSA patient-derived iPSCs. (A) Short tandem repeat profiling provided the number of repeating units of 16 polymorphic microsatellite loci, to compare the donor fibroblast cells (reference) and the generated iPSCs and verify their origin. (B) G-banding revealed that the six iPSC lines showed a normal diploid karyotype (n = 46) and matched the sex of the donor patient. (C) Digital PCR allowed us to screen whether specific genomic regions accumulated duplications that may give a strong selective survival or growth advantage to iPSCs. Example of the scatter digital PCR plots displaying simultaneously (1) FAM signals, shown in purple and green to detect the target gene ( ID1 , NCAPD2 , PITX1 , RPS6KB1 , SOAT1 , or <t>STS</t> ), which are located in the 6 most recurrent abnormal regions; and (2) VIM signals, shown in orange and green to detect the reference gene, RPP30 . The ratio between the number of copies of the target gene and of the reference gene was used to determine the normal 2-copy number or copy number variations. The plots were obtained through QuantStudio 3D Digital PCR system. In all cases, we obtained 2-copy number (D) Quantitative Real Time RT-PCR was used for confirming the absence of the Sendai virus in the iPSC lines after 8 passages, through four primer sets (SeV, KOS, Klf4 and c-Myc). Box and Whisker plots depict in log10 scale the gene expression relative to GAPDH gene and normalized to the 7 days post-transduction fibroblasts, calculated by the 2(-ΔΔC(T)) method. In all iPSC clones, the expression levels of the SeV RNA were very low, reaching the limit of detection. Data are shown as the mean ± s.d. n = 3.
Copy Number Variation Vps13b Mm00446968 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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copy number variation cyp2d6 hs00010001 cn  (Thermo Fisher)
94
Thermo Fisher copy number variation cyp2d6 hs00010001 cn
Three <t>CYP2D6</t> activity levels were defined: null/low (genotype-determined activity score [AS] ≤ 0.25), intermediate (AS between 0.5 and 1.0), and normal/high (AS > 1.0). The shaded areas surrounding the lines represent 95% confidence intervals. The P value of 0.0237 was obtained with a log-rank test comparing the three survival curves, rejecting the null hypothesis that groups with different CYP2D6 activity levels share an identical survival curve.
Copy Number Variation Cyp2d6 Hs00010001 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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copy number variation rela hs02229145 cn  (Thermo Fisher)
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Thermo Fisher copy number variation rela hs02229145 cn
Three <t>CYP2D6</t> activity levels were defined: null/low (genotype-determined activity score [AS] ≤ 0.25), intermediate (AS between 0.5 and 1.0), and normal/high (AS > 1.0). The shaded areas surrounding the lines represent 95% confidence intervals. The P value of 0.0237 was obtained with a log-rank test comparing the three survival curves, rejecting the null hypothesis that groups with different CYP2D6 activity levels share an identical survival curve.
Copy Number Variation Rela Hs02229145 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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copy number variation prodh hs04080831 cn  (Thermo Fisher)
94
Thermo Fisher copy number variation prodh hs04080831 cn
Three <t>CYP2D6</t> activity levels were defined: null/low (genotype-determined activity score [AS] ≤ 0.25), intermediate (AS between 0.5 and 1.0), and normal/high (AS > 1.0). The shaded areas surrounding the lines represent 95% confidence intervals. The P value of 0.0237 was obtained with a log-rank test comparing the three survival curves, rejecting the null hypothesis that groups with different CYP2D6 activity levels share an identical survival curve.
Copy Number Variation Prodh Hs04080831 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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copy number variation fgfr2 hs05182482 cn  (Thermo Fisher)
85
Thermo Fisher copy number variation fgfr2 hs05182482 cn
Three <t>CYP2D6</t> activity levels were defined: null/low (genotype-determined activity score [AS] ≤ 0.25), intermediate (AS between 0.5 and 1.0), and normal/high (AS > 1.0). The shaded areas surrounding the lines represent 95% confidence intervals. The P value of 0.0237 was obtained with a log-rank test comparing the three survival curves, rejecting the null hypothesis that groups with different CYP2D6 activity levels share an identical survival curve.
Copy Number Variation Fgfr2 Hs05182482 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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copy number variation met hs02323823 cn  (Thermo Fisher)
93
Thermo Fisher copy number variation met hs02323823 cn
Three <t>CYP2D6</t> activity levels were defined: null/low (genotype-determined activity score [AS] ≤ 0.25), intermediate (AS between 0.5 and 1.0), and normal/high (AS > 1.0). The shaded areas surrounding the lines represent 95% confidence intervals. The P value of 0.0237 was obtained with a log-rank test comparing the three survival curves, rejecting the null hypothesis that groups with different CYP2D6 activity levels share an identical survival curve.
Copy Number Variation Met Hs02323823 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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copy number variation rnf144b hs00358836 cn  (Thermo Fisher)
86
Thermo Fisher copy number variation rnf144b hs00358836 cn
Three <t>CYP2D6</t> activity levels were defined: null/low (genotype-determined activity score [AS] ≤ 0.25), intermediate (AS between 0.5 and 1.0), and normal/high (AS > 1.0). The shaded areas surrounding the lines represent 95% confidence intervals. The P value of 0.0237 was obtained with a log-rank test comparing the three survival curves, rejecting the null hypothesis that groups with different CYP2D6 activity levels share an identical survival curve.
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Image Search Results


Assessment of the cell line identity and the genomic integrity of the six MSA patient-derived iPSCs. (A) Short tandem repeat profiling provided the number of repeating units of 16 polymorphic microsatellite loci, to compare the donor fibroblast cells (reference) and the generated iPSCs and verify their origin. (B) G-banding revealed that the six iPSC lines showed a normal diploid karyotype (n = 46) and matched the sex of the donor patient. (C) Digital PCR allowed us to screen whether specific genomic regions accumulated duplications that may give a strong selective survival or growth advantage to iPSCs. Example of the scatter digital PCR plots displaying simultaneously (1) FAM signals, shown in purple and green to detect the target gene ( ID1 , NCAPD2 , PITX1 , RPS6KB1 , SOAT1 , or STS ), which are located in the 6 most recurrent abnormal regions; and (2) VIM signals, shown in orange and green to detect the reference gene, RPP30 . The ratio between the number of copies of the target gene and of the reference gene was used to determine the normal 2-copy number or copy number variations. The plots were obtained through QuantStudio 3D Digital PCR system. In all cases, we obtained 2-copy number (D) Quantitative Real Time RT-PCR was used for confirming the absence of the Sendai virus in the iPSC lines after 8 passages, through four primer sets (SeV, KOS, Klf4 and c-Myc). Box and Whisker plots depict in log10 scale the gene expression relative to GAPDH gene and normalized to the 7 days post-transduction fibroblasts, calculated by the 2(-ΔΔC(T)) method. In all iPSC clones, the expression levels of the SeV RNA were very low, reaching the limit of detection. Data are shown as the mean ± s.d. n = 3.

Journal: Frontiers in Immunology

Article Title: Generation and characterization of human induced pluripotent stem cells from neuropathologically confirmed multiple system atrophy patient-derived fibroblasts

doi: 10.3389/fimmu.2026.1641981

Figure Lengend Snippet: Assessment of the cell line identity and the genomic integrity of the six MSA patient-derived iPSCs. (A) Short tandem repeat profiling provided the number of repeating units of 16 polymorphic microsatellite loci, to compare the donor fibroblast cells (reference) and the generated iPSCs and verify their origin. (B) G-banding revealed that the six iPSC lines showed a normal diploid karyotype (n = 46) and matched the sex of the donor patient. (C) Digital PCR allowed us to screen whether specific genomic regions accumulated duplications that may give a strong selective survival or growth advantage to iPSCs. Example of the scatter digital PCR plots displaying simultaneously (1) FAM signals, shown in purple and green to detect the target gene ( ID1 , NCAPD2 , PITX1 , RPS6KB1 , SOAT1 , or STS ), which are located in the 6 most recurrent abnormal regions; and (2) VIM signals, shown in orange and green to detect the reference gene, RPP30 . The ratio between the number of copies of the target gene and of the reference gene was used to determine the normal 2-copy number or copy number variations. The plots were obtained through QuantStudio 3D Digital PCR system. In all cases, we obtained 2-copy number (D) Quantitative Real Time RT-PCR was used for confirming the absence of the Sendai virus in the iPSC lines after 8 passages, through four primer sets (SeV, KOS, Klf4 and c-Myc). Box and Whisker plots depict in log10 scale the gene expression relative to GAPDH gene and normalized to the 7 days post-transduction fibroblasts, calculated by the 2(-ΔΔC(T)) method. In all iPSC clones, the expression levels of the SeV RNA were very low, reaching the limit of detection. Data are shown as the mean ± s.d. n = 3.

Article Snippet: STS , Hs00091141_cn , FAM , Xp22 , hg38|7350117-7350227 , 110 bp , MseI, HindIII, CviQI.

Techniques: Derivative Assay, Generated, Digital PCR, Quantitative RT-PCR, Virus, Whisker Assay, Gene Expression, Transduction, Clone Assay, Expressing

Three CYP2D6 activity levels were defined: null/low (genotype-determined activity score [AS] ≤ 0.25), intermediate (AS between 0.5 and 1.0), and normal/high (AS > 1.0). The shaded areas surrounding the lines represent 95% confidence intervals. The P value of 0.0237 was obtained with a log-rank test comparing the three survival curves, rejecting the null hypothesis that groups with different CYP2D6 activity levels share an identical survival curve.

Journal: PLOS Neglected Tropical Diseases

Article Title: Reduced cytochrome P-450 (CYP) 2D6 activity and Plasmodium vivax malaria risk in Amazonians: A retrospective, population-based cohort study

doi: 10.1371/journal.pntd.0014160

Figure Lengend Snippet: Three CYP2D6 activity levels were defined: null/low (genotype-determined activity score [AS] ≤ 0.25), intermediate (AS between 0.5 and 1.0), and normal/high (AS > 1.0). The shaded areas surrounding the lines represent 95% confidence intervals. The P value of 0.0237 was obtained with a log-rank test comparing the three survival curves, rejecting the null hypothesis that groups with different CYP2D6 activity levels share an identical survival curve.

Article Snippet: The Hs00010001_cn assay (Thermo Fisher Scientific) was used estimate the CYP2D6 gene copy number; activity values were multiplied when multiple CYP2D6 allele copies were present ( ).

Techniques: Activity Assay